ABSTRACT
Coronavirus disease-2019 (COVID-19) is a novel disease that has become a global health problem with high mortality rates. Up to now, there is neither specific treatment nor a vaccine for the disease;hence, the primary goal is to keep patients alive. There is growing evidence that more men than women are dying from the COVID-19. Although the outbreak of COVID-19 has led to the legislation of exceptional public health measures in various countries, fatality difference among genders has not been changed in favor of women. It is important to understand the role of sex to figure out who is most vulnerable to COVID-19 and the risk factors of death. While the precise mechanism of globally observed lower female death rates is still unknown, there are many speculations such as the effect of X chromosome, immunologic distinction, lifestyle choices, and employment status. The aim of this review is to highlight the most relevant connections between COVID-19 and low mortality rate in women globally.